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Search Results for " hela cells "

117

抑制剂 & 化合物

60

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T21992	Vacuolin-1	PI3K; Autophagy	Autophagy; PI3K/Akt/mTOR signaling
	Vacuolin-1 是一种细胞渗透性抑制剂，可抑制 Ca2+ 依赖性溶酶体与细胞膜的融合。它通过抑制溶酶体内容物的释放起作用。它是一种有效的选择性 PIKfyve 抑制剂，通过损害溶酶体成熟来抑制晚期自噬。
T6421	BRD73954	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	BRD73954 是一种有效且特异性的 HDAC 抑制剂，对 HDAC6 和 HDAC8 的 IC50 分别为 36 nM 和 120 nM。
T12579	RAMB4 PTP1B-IN-9	Proteasome	Proteases/Proteasome; Ubiquitination
	RAMB4 (PTP1B-IN-9) 是一种泛素-蛋白酶体系统(UPS)应激源，是通过抑制 20S 蛋白酶体催化活性物质上游泛素介导的蛋白质降解而产生。它能够在不影响 20S 蛋白酶体催化活性的情况下触发泛素蛋白酶体系统 (UPS) 应激反应。
T7020	Z-VAD-FMK Z-VAD(OH)-FMK,Caspase Inhibitor VI,Z-VAD	Caspase	Apoptosis; Proteases/Proteasome
	Z-VAD-FMK (Caspase Inhibitor VI) 是一种 caspase 的广谱抑制剂，具有不可逆性。Z-VAD-FMK 与活化的 caspase 结合，从而抑制细胞凋亡。
T9079	Apostatin-1 Apt-1	Others	Others
	Apostatin-1 (Apt-1) 是一种新型 TRADD 抑制剂。 Apostatin-1 可以与 TRADD 的 N 末端 TRAF2 结合域上的口袋结合。
T11657	INH154	Others	Others
	INH154 是一种高效的 Nek2 和 Hec1 结合抑制剂，能够抑制 Hela 细胞(IC50:200 nM)、 MB468 细胞(IC50:120 nM)。
T25214	CCR-11 CCR11,CCR 11	Antibiotic	Microbiology/Virology
	CCR-11 是一种具有抗菌活性的绕丹宁衍生物。 CCR-11 可以抑制 B. subtilis细胞和 HeLa 细胞增殖。 CCR-11 通过抑制 FtsZ 的组装和 GTPase 活性来抑制细菌增殖和细菌胞质分裂。 CCR-11 具有潜在的抗肿瘤活性，可用于研究乳腺癌和小儿骨髓增生异常。
T77771	Compound 10w	Others	Others
	Compound 10w，一种取代吡唑并[1,5-a]嘧啶酰胺化合物，是一种ZSTK474 类似物，对 HeLa细胞显示出抗癌活性。
T25969	Poloxin-2 Poloxin2,Poloxin 2	PLK	Cell Cycle/Checkpoint
	Poloxin-2 是一种具有有效性和选择性的 Plk1 PBD 抑制剂，具有抗肿瘤活性，可降低HeLa细胞中Plk1的蛋白水平。
T5342	IWP-O1	Wnt/beta-catenin; Porcupine	Cytoskeletal Signaling; Stem Cells
	IWP-O1 是 Porcn 抑制剂，在 L-Wnt-STF 细胞中的 EC50值为 80 pM。它能够抑制 Wnt 蛋白分泌，可以抑制 HeLa 细胞中 Dvl2/3 和 LRP6 磷酸化。
T8623	TMIFRY8XAG 4,4,-二(4-氟苯)氯丁烷,1,1'-(4-CHLOROBUTYLIDENE)BIS(4-FLUOROBENZENE),4-oxo-1,4-dihydroquinoline-2-carboxylic acid	Others	Others
	TMIFRY8XAG (4-oxo-1,4-dihydroquinoline-2-carboxylic acid) 是 Zerumbone 的衍生物，对 HeLa 癌细胞具有潜在的抗肿瘤作用。
T8903	Retro-2 Retro 2,2-{[(5-methyl-2-thienyl)methylene]amino}	Others; Virus Protease; Parasite; Autophagy	Autophagy; Microbiology/Virology; Others
	Retro-2 (2-{[(5-methyl-2-thienyl)methylene]amino}) 是一种植物毒素蓖麻毒素抑制剂，它保护 HeLa 细胞免受蓖麻毒素、Stx1 和 Stx2 的侵害，选择性地阻断早期内体蛋白质-高尔基体界面处的逆行毒素运输。
T7426	ALSTERPAULLONE	Apoptosis; GSK-3; CDK	Apoptosis; Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling; Stem Cells
	Alsterpaullone 是高效的 CDK 抑制剂，是一种 ATP 竞争性的 GSK-3alpha/GSK-3beta 抑制剂，且作用的 IC50值都为 4 nM。它有用于神经退行性和增生性疾病的研究潜力，具有抗肿瘤活性，诱导白血病细胞凋亡。
T22264	AZ9482	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	AZ9482 是一种选择性 PARP1/2/6的三重抑制剂，IC50值分别为 1 、1 和640 nM。
T60485	DIF-3
	DIF-3 is a chemical compound that acts by activating GSK-3β to facilitate the degradation of cyclin D1 and c-Myc, resulting in reduced expression levels of these proteins. In addition, DIF-3 inhibits Wnt/β-catenin signaling pathway-related proteins in DLD-1 cells. This compound exerts a potent antiproliferative effect on the HeLa human cervical cancer cell line by inducing cyclin D1 degradation and inhibiting cyclin D1 mRNA expression [1].
T37020	Endosidin-2 ES2,Endosidin 2
	Endosidin-2是一种囊外囊抑制剂,具有细胞渗透性的亚苄基苯甲酰肼，可与外囊复合体70 kDa（EXO70）亚基的外囊成分结合（Kd = 253 μM，EXO70A1）。Endosidin-2会破坏蛋白质在内质体和质膜之间的转运，从而促进蛋白质转运至液泡降解。它还能抑制 HeLa 细胞中内吞转铁蛋白向质膜的再循环，并能靶向哺乳动物 EXO70的多种异构体，导致外泌失调。Endosidin2 可作为工具分子研究胞吐。
T13858	RA190	Proteasome	Proteases/Proteasome; Ubiquitination
	RA190 能够与泛素受体 RPN13 的半胱氨酸 88 共价结合，并抑制蛋白酶体功能。
T76784	Tildrakizumab MK 3222,SCH 900222	IL Receptor	Immunology/Inflammation
	Tildrakizumab (SCH 900222) 是一种有效的人源化抗-IL-23 (p19 亚基) 单克隆抗体。Tildrakizumab 靶向单链 IL-23 ，Kd 值为 136 pM。Tildrakizumab 可用于研究银屑病和牛皮癣。
T73590	8-Phenyl-2,6-dibromo-1,3,5,7-tetramethyl BODIPY
	8-Phenyl-2,6-dibromo-1,3,5,7-tetramethyl BODIPY 可用于光动力疗法。
T35610	2,5-dimethyl Celecoxib	Apoptosis; Wnt/beta-catenin; Prostaglandin Receptor	Apoptosis; Cytoskeletal Signaling; GPCR/G Protein; Immunology/Inflammation; Stem Cells
	2,5-dimethyl Celecoxib 是塞来昔布衍生物和微粒体前列腺素 E 合酶 1 (mPGES-1) 的靶向抑制剂，mPGES-1 是炎症介质 PGE2 合成途径中的关键酶。
T19841	Tribenoside Glyvenol,Glyvenal,Ba 2140,BG-356,Glivenol,三苄糖苷,TBGF	Others	Others
	Tribenoside (BG-356) 是血管保护剂，能够温和的镇痛、抗炎及伤口愈合，可用研究痔疮。
T3594	ML346	HSP	Cytoskeletal Signaling; Metabolism
	ML346是 Hsp70和 HSF-1活性的激活剂，针对 Hsp70 的 EC50为 4.6 μM。它诱导热休克反应 (HSR) 的基因和蛋白质效应子的特异性增加，如 Hsp70、Hsp40 和 Hsp27。
T18981	DMA	Others	Others
	DMA 是一种荧光试剂 (λex=340 nm, λem=478 nm)。
T68147	T-900607	Microtubule Associated	Cytoskeletal Signaling
	T-900607是一种新型微管蛋白活性剂，通过独特的作用机制破坏微管聚合。t-900607具有心脏毒性。
T15362	FX-11 LDHA Inhibitor FX11	Dehydrogenase	Metabolism
	FX-11 (LDHA Inhibitor FX11) 是一种有效的、选择性的和竞争性的乳酸脱氢酶 A (LDHA) 的特异性抑制剂，对LDHA 的Ki 为 8 μM。FX-11 对PKM2 (丙酮酸激酶 M2)具有激活作用。FX-11 可降低 ATP 水平，诱导氧化应激和ROS 生成，可引起细胞死亡。FX-11 在淋巴瘤和胰腺癌异种移植过程中表现出抗肿瘤活性。
T7181	IDO-IN-1 4-氨基-N-(3-溴-4-氟苯基)-N'-羟基-1,2,5-恶二唑-3-甲脒	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	IDO-IN-1 是吲哚胺-2,3-双加氧酶抑制剂，IC50=59 nM。
T16334	NMS-P515	Others	Others
	NMS-P515 is an effective, orally active, and stereospecific PARP-1 inhibitor (Kd: 16 nM and an IC50: 27 nM (in Hela cells)). It has anti-tumor activity.
T36816	S-trityl-L-Cysteine STLC	Kinesin	Cytoskeletal Signaling
	S-Trityl-L-cysteine 是别构驱动蛋白Eg5的选择性抑制剂。rityl-L-cysteine 抑制基础 ATPase 活性的IC50为 1 μM，抑制微管激活的 ATPase 活性的IC50为 140 nM。S-Trityl-L-cysteine 显示出抗肿瘤活性。
T4057	Hoechst 33258 trihydrochloride Hoechst 33258,Pibenzimol,Bisbenzimide,H 33258 trihydrochloride,bisBenzimide H 33258 trihydrochloride,HOE 33258	Parasite	Microbiology/Virology
	Hoechst 33258 trihydrochloride (Bisbenzimide) 是一种能够用于 DNA 染色的荧光染料。
T24530	NHI-2 NHI 2
	NHI-2 is an inhibitor of LDHA that acts by reducing lactate production in HeLa cells.
T63765	L5-DA
	L5-DA 是一种 G-四链体(G4)配体，能够选择性稳定 G4s。L5-DA 对 HeLa 细胞表现出明显的细胞毒性，其 IC50 值为 4.3 μM。L5-DA 能够稳定 HeLa 细胞中的 G4s，并可阻滞细胞周期及诱导细胞凋亡。
T29014	Tripartin
	Tripartin specifically inhibits the histone H3 lysine 9 demethylase KDM4 in HeLa cells.
T10464L	Atuveciclib Racemate BAY-1143572 Racemate,阿维西利	CDK	Cell Cycle/Checkpoint
	Atuveciclib Racemate (BAY-1143572 Racemate) 是 Atuveciclib 的外消旋混合物。 Atuveciclib 是口服有效的 P-TEFb/CDK9高选择性抑制剂，CDK9/CycT1的 IC50为13 nM。
T73111	IDO1-IN-17
	IDO1-IN-17 (I-4) 是IDO1的抑制剂，其在 hela 细胞中的IC50值为 0.44 μM。
T36202	Citreoindole
	Citreoindole is a diketopiperazine metabolite isolated from a hybrid cell fusion of two strains of P. citreovirde that is cytotoxic in vitro against HeLa cells at 8.4 μM.
T11419	O6BTG-octylglucoside Glucose-conjugated MGMT inhibitor	Others	Others
	O6BTG-octylglucoside is a potent O6-methylguanine-DNAmethyl-transferase (MGMT) inhibitor (IC50s: 10 nM and 32 nM in HeLa S3 cells and in vitro (cell extracts)).
T82632	Cys-C-cGMP	AUTACs	PROTAC
	Cys-C-cGMP 为一种AUTACs自噬标签。它能够促进HeLa细胞线粒体K63链式连接的泛素化增加。
T63455	PI3K/Akt/mTOR-IN-3
	PI3K/Akt/mTOR-IN-3 是 PI3K/Akt/mTOR 的有效抑制剂。PI3K/Akt/mTOR-IN-3 能够抑制 MCF-7 细胞 (IC50: 0.77 μM)、HeLa 细胞 (IC50: 1.23 μM) 和 HepG2 细胞(IC50: 4.57 μM)。PI3K/Akt/mTOR-IN-3 在 4 μM 浓度下可抑制 MCF-7 和 HeLa 细胞的迁移。PI3K/Akt/mTOR-IN-3 能够将细胞周期阻滞在 S 期，并诱导细胞凋亡 (apoptosis)。
T36693	FD-211
	FD-211 is a δ lactone originally isolated from M. lutea with anticancer activity.1 It is cytotoxic to adriamycin-susceptible P388, T-24, HeLa, A549, and HL-60 cancer cells (IC50s = 4, 0.5, 1, 1, and 0.2 μg/ml, respectively), as well as adriamycin-resistant HL-60/ADR cells (IC50 = 0.1 μg/ml). FD-211 also inhibits DNA, RNA, and protein synthesis in HeLa cells (IC50 = 1.25 μg/ml for all). \|1. Nozawa, O., Okazaki, T., Sakai, N., et al. A novel bioactive δ lactone FD-211. Taxonomy, isolation and char...
T63354	Anticancer agent 17
	Anticancer agent 17 对 HeLa 细胞 (IC50: 0.19 μM) 和 A2780 细胞 (IC50: 0.09 μM) 具有有效抗癌作用。
T63879	microRNA-21-IN-1
	microRNA-21-IN-1（compound 7A）是一种高效microRNA抑制剂，对Hela和HCT-116细胞显示出抗增殖活性，IC50值分别为5.5 μM和2.8 μM，并能促进Hela细胞凋亡(apoptosis)。该化合物通过上调microRNA-21下游功能靶点（PTEN、EGR1、SLIT2）的表达，有助于抗癌研究。
T81962	Lactate transportor 1	Monocarboxylate transporter	Membrane transporter/Ion channel
	Lactate transporter 1 (compound 1) 作为一种活性乳酸运输蛋白，主要在活细胞内发挥作用。在Hela、CAL27、MCF7和MCF10A细胞系中，Lactate transporter 1 均显示出了明显的毒性，其半抑制浓度（IC50）值依次为3.36、3.27、5.58和7.66 μM。此外，在HeLa细胞中，Lactate transporter 1 与Cisplatin表现出了协同抑制的作用。
T10200	9-Hydroxyellipticine hydrochloride	Others	Others
	9-Hydroxyellipticine hydrochloride is a inhibitor of Topo II and RyR. It exhibits antitumor, antioxidant and catecholamine-releasing activities. 9-Hydroxyellipticine hydrochloride inihibits Hela S-3 and 293T cells (IC50s: 1.6 μM and 1.2μM).
T62966	IQTub4P
	IQTub4P 是一种有效的微管 (microtubule) 抑制剂。IQTub4P 在 HeLa 细胞中表现出细胞毒性 (EC50: 170 nM)。IQTub4P 在体内耐受良好，可以抑制微管结构和功能。
T62399	Apoptosis inducer 10
	Apoptosis inducer 10 是一种有效的细胞凋亡诱导剂，具有抗增殖活性。Apoptosis inducer 10 利用线粒体依赖性内源性途径，诱导 HeLa 癌细胞凋亡 (apoptosis)。
T69073	COTC
	COTC is a bacterial metabolite that has anticancer activity and inhibits glyoxalase in the presence of glutathione (GSH) and the proliferation of HeLa cells, as well as reduces tumor growth and improves survival in an Ehrlich murine spontaneous adenocarcinoma model.
T37198	Ethyl LipotF
	Selective FTO inhibitor (IC50 = 0.81 μM). Exhibits >30-fold selectivity for FTO over ALKBH2, 3 and 5 and >100-fold selectivity over PHD2 and JMJD2A. Increases levels of modified N6-methyladenosine (m6A) in HeLa cells in a concentration-dependent manner.
T36969	ARN24139
	ARN24139 is a topoisomerase II poison (IC50= 7.3 μM in a topoisomerase II decatenation assay).1It inhibits proliferation of DU145, HeLa, and A549 cells (IC50s = 4.7, 3.8, and 3.1 μM, respectively). 1.Arencibia, J.M., Brindani, N., Franco-Ulloa, S., et al.Design, synthesis, dynamic docking, biochemical characterization, and in vivo pharmacokinetics studies of novel topoisomerase II poisons with promising antiproliferative activityJ. Med. Chem.63(7)3508-3521(2020)
T63268	ERK5-IN-3
	ERK5-IN-3 是选择性的、有效的 ERK5 (细胞外信号相关激酶 5) 抑制剂 (IC50: 6 nM)。ERK5-IN-3 对 Hela 细胞表现出抗增殖作用 (IC50: 31 nM)。
T62163	Hsp90-IN-15
	Hsp90-IN-15 是一种 Hsp90 抑制剂，具有抗癌作用。Hsp90-IN-15 能够将细胞周期阻滞在 S 期，诱导细胞凋亡 (apoptosis)，并可以减少 Hela 细胞中 Hsp90 的表达水平。

化合物

Cat.No: T21992

Target: PI3K, Autophagy

Cat.No: T6421

Target: HDAC

Cat.No: T12579

Synonym: PTP1B-IN-9

Target: Proteasome

Cat.No: T7020

Synonym: Z-VAD(OH)-FMK,Caspase Inhibitor VI,Z-VAD

Target: Caspase

Cat.No: T9079

Synonym: Apt-1

Target: Others

Cat.No: T11657

Target: Others

Cat.No: T25214

Synonym: CCR11,CCR 11

Target: Antibiotic

Cat.No: T77771

Target: Others

Cat.No: T25969

Synonym: Poloxin2,Poloxin 2

Target: PLK

Cat.No: T5342

Target: Wnt/beta-catenin, Porcupine

Cat.No: T8623

Synonym: 4,4,-二(4-氟苯)氯丁烷,1,1'-(4-CHLOROBUTYLIDENE)BIS(4-FLUOROBENZENE),4-oxo-1,4-dihydroquinoline-2-carboxylic acid

Target: Others

Cat.No: T8903

Synonym: Retro 2,2-{[(5-methyl-2-thienyl)methylene]amino}

Target: Others, Virus Protease, Parasite, Autophagy

Cat.No: T7426

Target: Apoptosis, GSK-3, CDK

Cat.No: T22264

Target: PARP

Cat.No: T60485

Cat.No: T37020

Synonym: ES2,Endosidin 2

Cat.No: T13858

Target: Proteasome

Cat.No: T76784

Synonym: MK 3222,SCH 900222

Target: IL Receptor

8-Phenyl-2,6-dibromo-1,3,5,7-tetramethyl BODIPY

Cat.No: T73590

2,5-dimethyl Celecoxib

Cat.No: T35610

Target: Apoptosis, Wnt/beta-catenin, Prostaglandin Receptor

Cat.No: T19841

Synonym: Glyvenol,Glyvenal,Ba 2140,BG-356,Glivenol,三苄糖苷,TBGF

Target: Others

Cat.No: T3594

Target: HSP

Cat.No: T18981

Target: Others

Cat.No: T68147

Target: Microtubule Associated

Cat.No: T15362

Synonym: LDHA Inhibitor FX11

Target: Dehydrogenase

Cat.No: T7181

Synonym: 4-氨基-N-(3-溴-4-氟苯基)-N'-羟基-1,2,5-恶二唑-3-甲脒

Target: Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T16334

Target: Others

S-trityl-L-Cysteine

Cat.No: T36816

Synonym: STLC

Target: Kinesin

Hoechst 33258 trihydrochloride

Cat.No: T4057

Synonym: Hoechst 33258,Pibenzimol,Bisbenzimide,H 33258 trihydrochloride,bisBenzimide H 33258 trihydrochloride,HOE 33258

Target: Parasite

Cat.No: T24530

Synonym: NHI 2

Cat.No: T63765

Cat.No: T29014

Atuveciclib Racemate

Cat.No: T10464L

Synonym: BAY-1143572 Racemate,阿维西利

Target: CDK

Cat.No: T73111

Cat.No: T36202

O6BTG-octylglucoside

Cat.No: T11419

Synonym: Glucose-conjugated MGMT inhibitor

Target: Others

Cat.No: T82632

Target: AUTACs

PI3K/Akt/mTOR-IN-3

Cat.No: T63455

Cat.No: T36693

Anticancer agent 17

Cat.No: T63354

microRNA-21-IN-1

Cat.No: T63879

Lactate transportor 1

Cat.No: T81962

Target: Monocarboxylate transporter

9-Hydroxyellipticine hydrochloride

Cat.No: T10200

Target: Others

Cat.No: T62966

Apoptosis inducer 10

Cat.No: T62399

Cat.No: T69073

Cat.No: T37198

Cat.No: T36969

Cat.No: T63268

Cat.No: T62163

Cat. No.	Product Name	Target	Signaling Pathways
T11363	Ganoderic acid F	Others	Others
	Ganoderic acid F 是一种灵芝酸。它具有抗肿瘤和抗转移的活性，与抑制血管生成和涉及细胞增殖和细胞死亡，致癌作用，氧化应激，钙信号传导和内质网应激的蛋白质改变等机制相关。
T13475	β-Aminopropionitrile 3-氨基丙腈,3-Aminopropionitrile,BAPN	Others; Endogenous Metabolite	Metabolism; Others
	β-Aminopropionitrile (3-Aminopropionitrile) 是赖氨酰氧化酶的特异性抑制剂。
T3673	Mollugin 大叶茜草素,Rubimaillin	HER; JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Mollugin (Rubimaillin) 是Rubia cordifolia L.中主要的生物活性成分。它能通过 p38-Smad 信号通路增强 BMP-2 的成骨作用。它通过抑制 TNF-α 诱导的 NF-κB 激活起抗癌疗效。
T14046	Anandamide 花生四烯酸乙醇胺,(5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide	Cannabinoid Receptor; Endogenous Metabolite	GPCR/G Protein; Metabolism
	Anandamide ((5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide) 是一种免疫调节剂，通过大麻素受体 CB1 和 CB2 起作用，还通过中枢神经系统中的其他靶点起作用，如 GPR18/GPR55。
TN4375	Kamebanin	Antifection	Microbiology/Virology
	Kamebanin 是一种天然二萜类化合物，具有抗菌活性。它对 HeLa 和 HL-60 细胞显示出有效的细胞毒活性。
TN7041	(-)-Epipodophyllotoxin	Apoptosis	Apoptosis
	(-)-Epipodophyllotoxin 是一种从八角莲中分离的癌细胞抗增殖剂，在 HeLa 细胞和 MCF-7 细胞中的GI50值分别为 0.36 和 0.24 μM。它可在体外抑制有丝分裂纺锤体组装。
TQ0170	Desacetylcinobufagin Deacetylcinobufagin,去乙酰华蟾蜍精	Others	Others
	Desacetylcinobufagin (Deacetylcinobufagin) 是一种天然化合物，可用于微生物转化。
T5738	7-Epi 10-desacetyl paclitaxel 10-Deacetyl-7-epipaclitaxel,7-Epi-10-deacetyltaxol,7-表-10-去乙酰基云南紫杉宁A	Others	Others
	7-Epi 10-desacetyl paclitaxel (10-Deacetyl-7-epipaclitaxel) 是紫杉醇衍生物，对 HeLa 细胞具有细胞毒性(IC50:85 μM)。
TN1916	Matairesinol 罗汉松树脂酚	ATPase; p38 MAPK; ROS	Immunology/Inflammation; MAPK; Membrane transporter/Ion channel
	Matairesinol has radical and superoxide scavenging activities,; it also has anti-angiogenic activity by suppressing mROS signaling , can decrease hypoxia-inducible factor-1α± in hypoxic HeLa cells.
T3395	Timosaponin AIII Filiferin B,知母皂苷 A-III,AneMarsaponin A3,Timosaponin A3	AChE; mTOR	Neuroscience; PI3K/Akt/mTOR signaling
	Timosaponin AIII (Timosaponin A3) 是一种乙酰胆碱酯酶活性抑制剂，其IC50=35.4 μM。
T5S1133	Ganoderic acid D 灵芝酸D,灵芝酸 D	Apoptosis; Sirtuin	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Ganoderic acid D 是高度氧化的四环三萜，是灵芝的主要活性成分，可诱导 HeLa 人宫颈癌细胞凋亡。它上调 SIRT3的蛋白质表达并通过 SIRT3 诱导脱乙酰化的亲环蛋白 D 。它抑制结肠癌细胞的能量重编程，包括结肠癌细胞中的葡萄糖摄取，乳酸、丙酮酸和乙酰辅酶的产生。
TN1393	(-)-Anonaine 番荔枝碱	Apoptosis; Antioxidant; Parasite; Antifungal	Apoptosis; Microbiology/Virology; oxidation-reduction
	(-)-Anonaine 可从木兰科和安妮科的几个物种中提取出来，具有抗疟、抗菌、抗真菌、抗氧化、抗癌、抗抑郁和血管舒张的活性。(-)-Anonaine 通过 Bax 和 caspase 依赖性途径诱导人类宫颈癌（HeLa）细胞的凋亡，诱导 DNA 损伤并抑制人类肺癌 h1299细胞的生长和迁移。
T3386	Kaempferitrin Lespedin,Kaempferol,Lespenephryl,Lespenefril,Kaempferol 3,7-dirhamnoside,山奈苷	cell cycle arrest; Glucokinase; IGF-1R	Cell Cycle/Checkpoint; Metabolism; Tyrosine Kinase/Adaptors
	Kaempferitrin (Lespenephryl) 是天然黄酮苷类化合物，具有缓解疼痛、抗糖尿病、消炎、抗肿瘤和化疗作用，可激活胰岛素信号传导。
T5S0055	Chelidonine Helidonine,Khelidonin,白屈菜碱,Stylophorin	Apoptosis; Others; Influenza Virus	Apoptosis; Microbiology/Virology; Others
	Chelidonine (Stylophorin) 是白屈菜中的一种异喹啉生物碱，有抗肿瘤和抗病毒作用。它可导致细胞周期 G2/M 停滞，诱导 caspase 依赖和非依赖性的细胞凋亡。
T1879	3-Methyladenine 3-MA,3-甲基腺嘌呤,NSC 66389	Mitophagy; PI3K; Endogenous Metabolite; Autophagy	Autophagy; Metabolism; PI3K/Akt/mTOR signaling
	3-Methyladenine (3-MA) 是一种 PI3K 抑制剂，选择性抑制 IB 类 PI3Kγ (IC50=60 μM) 和 III 类 VPS34 (IC50=25 μM)。3-Methyladenine 具有自噬抑制活性。
T0190	Vinorelbine 长春瑞宾,KW-2307 base	Microtubule Associated	Cytoskeletal Signaling
	Vinorelbine (KW-2307 base) 是一种半合成的长春花生物碱。它与微管蛋白结合并阻止有丝分裂纺锤体的形成，导致中期肿瘤细胞生长停滞。
T4036	Solasodine Solancarpidine,Purapuridine,澳洲茄铵,Solasodin	Apoptosis; Others; E1/E2/E3 Enzyme; Antifungal	Apoptosis; Microbiology/Virology; Others; Ubiquitination
	Solasodine (Purapuridine) 是存在于茄科植物中的一种类固醇生物碱。它具有神经保护、降压、抗真菌、抗癌、抗动脉粥样硬化、抗雄激素和抗炎活性。
T0122	Bergenin Cuscutin,Bengenin,岩白菜素	Apoptosis; IL Receptor; Virus Protease; TNF; NF-κB; Antibacterial; NOD; Autophagy; Antifungal	Apoptosis; Autophagy; Immunology/Inflammation; Microbiology/Virology; NF-κB
	Bergenin (Bengenin) 是一种在许多药用植物中发现的多酚，有细胞保护和抗氧化作用。它还具有广泛的保肝、抗炎、抗肿瘤、抗病毒、抗真菌以及免疫调节作用。
TN6569	cis-Moschamine
	cis-Moschamine exerts antitumour effects on HeLa, MCF7 and A431 cells.
TN3619	Cedrusin	PARP; Caspase	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Proteases/Proteasome
	Cedrusin shows a cytotoxic effect on A375 and HeLa cells.
T83481	1,1′-Disinomenine
	1,1'-Disinomenine，一种从Sinomenium acutum茎部分离得到的生物碱，对A549和Hela细胞表现出较弱的抑制效果。
TN3605	Casegravol	Others	Others
	Casegravol shows antiproliferative activity against human gastric adenocarcinoma (MK-1), human uterus carcinoma (HeLa), and murine melanoma (B16F10) cells.
TN2964	3'-Methylflavokawin	Others	Others
	3'-Methylflavokawin shows cytotoxicity against HeLa cells, the IC 50 value comparable to xanthohumol (8.2-19.2 microM).
T35234	Yadanzioside B
	Yadanzioside B 是提取自鸦胆子的苦木素苷类化合物。Yadanzioside B 能够抑制HeLa细胞中的蛋白质合成，但对体外翻译几乎没有影响。
TN1776	Isocucurbitacin B	Others	Others
	Isocucurbitacin B 对 HeLa 和 HT-29 人类癌细胞具有显着的抑制活性，IC50 值范围为 0.93 至 9.73uM。
T40440	Isobyakangelicol Isobyakangelicol,Anhydrobyakangelicin
	Isobyakangelicol, a coumarin compound present in Angelica dahurica roots, exhibits inhibitory effects on the growth of HeLa and HepG2 cells, with IC50 values of 70.04 μM and 17.97 μM, respectively.
T82982	Aplyronine C
	Aplyronine C是一种抗肿瘤活性化合物，对HeLa-S3细胞表现出细胞毒性，其IC50为2.9 nM，适用于癌症研究。
TN5336	9-Oxo-10,11-dehydroageraphorone 4,7(11)-Cadinadiene-3,8-dione,DTD,7,11-Dehydro-8-oxoageraphorone,泽兰二酮
	9-Oxo-10,11-dehydroageraphorone has acaricidal activity. It induces hepatotoxicity and cholestasis in rats. 9-Oxo-10,11-dehydroageraphorone also effectively inhibits the proliferation of HeLa cells by arresting the cell cycle transition from S to G2/M pha
T13764	Lycopodine	Lipoxygenase; Caspase	Apoptosis; Metabolism; Proteases/Proteasome
	Lycopodine, a bioactive compound derived from Lycopodium clavatum spores, effectively inhibits the proliferation of HeLa cells through the induction of apoptosis. This process is mediated by caspase-3 activation. In refractory prostate cancer cells, Lycopodine triggers apoptosis by modulating 5-lipoxygenase and depolarizing the mitochondrial membrane potential, without altering p53 activity.
T82983	Aplyronine B
	Aplyronine B是一种具有抗肿瘤活性的活性化合物，对HeLa-S3细胞表现出细胞毒性，IC50值为2.9 nM，适用于癌症研究。
TN3049	4-Methoxycinnamyl alcohol	Others	Others
	4-Methoxycinnamyl alcohol 对MCF-7、HeLa 和DU145癌症细胞系显示出毒性，IC50值分别为14.24、7.82和22.10μg/mL。4-methoxycinnamyl alcohol 是从Foeniculum vulgare 中分离出来的。4-Methoxycinnamyl alcohol 没有显示出凋亡作用，却在10μg/mL DNA 碎片研究显示48小时后发生了坏死。
TN6645	Lucidumol A
	Lucidumol A has relatively good effect against aldose reductase with IC50 of 19.1uM. Lucidumol A has cytotoxic activity, it reduced cell growth in three human carcinoma cells (Caco-2, HepG2, and HeLa cells) dose dependently with LC50s from 20.87 to 84.36
T81818	Metachromins X
	Metachromins X，一倍半萜醌类化合物，能阻碍HeLa/Fucci2细胞在S/G2/M期的细胞周期。
T37444	Aranorosin
	Aranorosin is a fungal metabolite originally isolated from P. roseus. It has antimicrobial activity against B. subtilis, A. niger, and C. albicans when used at a concentration of 1 mg/ml. Aranorosin also reduces viability in apoptosis-resistant HeLa/Bcl-2 cells.
T79991	Condurango glycoside A
	Condurango glycoside A 作为p53激活剂，能够促进ROS的生成并且上调p53的表达。此外，Condurango glycoside A 还能够诱导HeLa细胞发生与DNA损伤相关的凋亡及过早老化。
TN4102	Ganoderic acid AM1	Others	Others
	Ganoderic acid AM1 treatment for 48 h inhibited the proliferation of HeLa human cervical carcinoma cells with IC(50) values of 19.8+/-0.7 microM.
TN6010	Picrasidine S
	Picrasidine S shows the potent cytotoxicity against human HeLa cervical, gastric MKN-28, and mouse melanoma B-16 cancer cells, it also shows the potent antibacterial activity against two strains of pathogenic bacteria methicillin-resistant Staphylococcus
TN5093	Taiwanhomoflavone A	COX	Immunology/Inflammation; Neuroscience
	Taiwanhomoflavone A is cytotoxic with ED50 values of 3.4, 1.0, 2.0 and 2.5 microg/ml, respectively, against KB epidermoid carcinoma of nasopharynx, COLO-205 colon carcinoma, Hepa-3B hepatoma, and Hela cervix tumor cells.
T75488	Leptosphaerodione
	Leptosphaerodione，可从 Remotididymellasp. 中分离得到，是一种有效的泛素-蛋白酶体系统 (UPS) 抑制剂。Leptosphaerodione 在 HeLa 细胞中具有细胞毒性，IC50为 3.2 μM。抗肿瘤剂。
T69368	GKK1032B
	GKK1032B is a fungal metabolite that has antiproliferative and antibacterial activities. GKK1032B inhibits the growth of HeLa S3 cervical and MCF-7 breast cancer cells and Vero cells. It also inhibits the growth of B. subtilis and M. tuberculosis.
T75490	27-O-(tert-Butyldimethylsilyl)withaferin A
	27-O-(tert-Butyldimethylsilyl)withaferin A (compound 9a) 为一种天然茄内酯类化合物，具备诱导细胞凋亡 (apoptosis) 的能力。该化合物对人类癌细胞系HeLa、A-549、MCF-7以及正常Vero细胞展现出抗增殖活性。
TN2872	3,4-Di-O-caffeoylquinic acid methyl ester 金银花	HSV	Microbiology/Virology
	3,4-Di-O-caffeoylquinic acid methyl ester shows high efficiency and low toxicity with antivirus activity against RSV; it exhibits cytotoxicity actions against human cervix carcinoma HeLa cells.
T36797	1-Alaninechlamydocin
	1-Alaninechalmydocin is a fungal metabolite originally isolated from a Great Lakes-derived Tolypocladium sp. and an inhibitor of histone deacetylases (HDACs). It reduces total HDAC activity in HeLa cell lysates in a concentration-dependent manner. 1-Alaninechlamydocin reduces proliferation of MIA PaCa-2, PANC-1, and hTERT-HPNE cells (GI50s = 5.3, 14, and 2.0 nM, respectively).
T75629	Ganoderic acid Mk
	Ganoderic acid Mk (GA-Mk)为来源于灵芝菌丝的三萜酸类化合物，能有效抑制细胞增殖，并通过线粒体途径诱导HeLa细胞的细胞凋亡(apoptosis)，在宫颈癌研究中具有应用价值。
TN2894	3,5-Di-O-caffeoylquinic acid methyl ester 金银花	HSV	Microbiology/Virology
	3,5-Di-O-caffeoylquinic acid methyl ester exhibits potent inhibitory activities against the formation of advanced glycation end products (AGEs); it exhibits cytotoxicity actions against human cervix carcinoma HeLa cells. 3,5-Di-O-caffeoylquinic acid methyl ester shows high efficiency and low toxicity with antivirus activity against RSV.
TN4194	Heliangin	IL Receptor; TNF; NF-κB; MAPK; Prostaglandin Receptor	Apoptosis; GPCR/G Protein; Immunology/Inflammation; MAPK; NF-κB
	Heliangin shows anti-inflammatory effects, it can inhibit lipopolysaccharide-induced inflammation through signaling NF-ÎºB pathway on LPS-induced RAW 264.7 cells. Heliangin has anti-cancer activity, it exhibits cytotoxicity against human oral epidermoid (
T37451	Stachybotrysin B
	Stachybotrysin B is a fungal metabolite originally isolated from S. chartarum and has antiviral and anticancer activities.1,2 It has antiviral activity against HIV in SupT1 cells (IC50 = 19.2 μM).1 Stachybotrysin B is cytotoxic to K562, HeLa, and HL-60 cells (IC50s = 21.72, 39.63, and 18.5 μM, respectively).2 \|1. Zhao, J., Feng, J., Tan, Z., et al. Stachybotrysins A-G, phenylspirodrimane derivatives from the fungus Stachybotrys chartarum. J. Nat. Prod. 80(6), 1819-1826 (2017).\|2. Ma, X.-h., Zhen...
T82859	Blepharotriol
	Blepharotriol为Maytenus blepharodes中发现的一种酚类三萜化合物。该化合物具有抗菌特性，对Bacillus subtilis的最小抑菌浓度（MIC）为8-4 µg/ml。此外，Blepharotriol在HeLa、Hep-2、Vero细胞上的半数抑制浓度（IC50）分别为12.2、>20、>20 µM，表明其具有一定的细胞毒性。
T36749	Herboxidiene
	Herboxidiene is a polyketide originally isolated from S. chromofuscus that has diverse biological activities.[1],[2,][3],[4],[5] It inhibits growth of HeLa S3, SK-MEL-2, PC3, A549, and EBC-1 cells with GI50 values ranging from 7.4 to 62 nM.3 Herboxidiene is cytostatic against human umbilical vein endothelial cells (HUVECs; (IC50 = 26 nM)) and inhibits VEGF-induced invasion and tube formation of serum-starved HUVECs in a concentration-dependent manner, indicating antiangiogenic activity.[4] Herbo...
TN3968	Epifriedelanol acetate	Others	Others
	Epifriedelanol exhibits antibacterial activities. It also can reduce cellular senescence in human primary cells and may be used to develop dietary supplements or cosmetics that modulate tissue aging or aging-associated diseases. Epifriedelanol and friedel
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天然产物

Ganoderic acid F

Cat.No: T11363

Target: Others

β-Aminopropionitrile

Cat.No: T13475

Synonym: 3-氨基丙腈,3-Aminopropionitrile,BAPN

Target: Others, Endogenous Metabolite

Cat.No: T3673

Synonym: 大叶茜草素,Rubimaillin

Target: HER, JAK

Cat.No: T14046

Synonym: 花生四烯酸乙醇胺,(5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide

Target: Cannabinoid Receptor, Endogenous Metabolite

Cat.No: TN4375

Target: Antifection

(-)-Epipodophyllotoxin

Cat.No: TN7041

Target: Apoptosis

Desacetylcinobufagin

Cat.No: TQ0170

Synonym: Deacetylcinobufagin,去乙酰华蟾蜍精

Target: Others

7-Epi 10-desacetyl paclitaxel

Cat.No: T5738

Synonym: 10-Deacetyl-7-epipaclitaxel,7-Epi-10-deacetyltaxol,7-表-10-去乙酰基云南紫杉宁A

Target: Others

Cat.No: TN1916

Synonym: 罗汉松树脂酚

Target: ATPase, p38 MAPK, ROS

Timosaponin AIII

Cat.No: T3395

Synonym: Filiferin B,知母皂苷 A-III,AneMarsaponin A3,Timosaponin A3

Target: AChE, mTOR

Ganoderic acid D

Cat.No: T5S1133

Synonym: 灵芝酸D,灵芝酸 D

Target: Apoptosis, Sirtuin

Cat.No: TN1393

Synonym: 番荔枝碱

Target: Apoptosis, Antioxidant, Parasite, Antifungal

Cat.No: T3386

Synonym: Lespedin,Kaempferol,Lespenephryl,Lespenefril,Kaempferol 3,7-dirhamnoside,山奈苷

Target: cell cycle arrest, Glucokinase, IGF-1R

Cat.No: T5S0055

Synonym: Helidonine,Khelidonin,白屈菜碱,Stylophorin

Target: Apoptosis, Others, Influenza Virus

3-Methyladenine

Cat.No: T1879

Synonym: 3-MA,3-甲基腺嘌呤,NSC 66389

Target: Mitophagy, PI3K, Endogenous Metabolite, Autophagy

Cat.No: T0190

Synonym: 长春瑞宾,KW-2307 base

Target: Microtubule Associated

Cat.No: T4036

Synonym: Solancarpidine,Purapuridine,澳洲茄铵,Solasodin

Target: Apoptosis, Others, E1/E2/E3 Enzyme, Antifungal

Cat.No: T0122

Synonym: Cuscutin,Bengenin,岩白菜素

Target: Apoptosis, IL Receptor, Virus Protease, TNF, NF-κB, Antibacterial, NOD, Autophagy, Antifungal

Cat.No: TN6569

Cat.No: TN3619

Target: PARP, Caspase

1,1′-Disinomenine

Cat.No: T83481

Cat.No: TN3605

Target: Others

3'-Methylflavokawin

Cat.No: TN2964

Target: Others

Cat.No: T35234

Isocucurbitacin B

Cat.No: TN1776

Target: Others

Isobyakangelicol

Cat.No: T40440

Synonym: Isobyakangelicol,Anhydrobyakangelicin

Cat.No: T82982

9-Oxo-10,11-dehydroageraphorone

Cat.No: TN5336

Synonym: 4,7(11)-Cadinadiene-3,8-dione,DTD,7,11-Dehydro-8-oxoageraphorone,泽兰二酮

Cat.No: T13764

Target: Lipoxygenase, Caspase

Cat.No: T82983

4-Methoxycinnamyl alcohol

Cat.No: TN3049

Target: Others

Cat.No: TN6645

Cat.No: T81818

Cat.No: T37444

Condurango glycoside A

Cat.No: T79991

Ganoderic acid AM1

Cat.No: TN4102

Target: Others

Cat.No: TN6010

Taiwanhomoflavone A

Cat.No: TN5093

Target: COX

Leptosphaerodione

Cat.No: T75488

Cat.No: T69368

27-O-(tert-Butyldimethylsilyl)withaferin A

Cat.No: T75490

3,4-Di-O-caffeoylquinic acid methyl ester

Cat.No: TN2872

Synonym: 金银花

Target: HSV

1-Alaninechlamydocin

Cat.No: T36797

Ganoderic acid Mk

Cat.No: T75629

3,5-Di-O-caffeoylquinic acid methyl ester

Cat.No: TN2894

Synonym: 金银花

Target: HSV

Cat.No: TN4194

Target: IL Receptor, TNF, NF-κB, MAPK, Prostaglandin Receptor

Stachybotrysin B

Cat.No: T37451

Cat.No: T82859

Cat.No: T36749

Epifriedelanol acetate

Cat.No: TN3968

Target: Others

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